强直性脊柱炎患者的骶髂关节炎：磁共振成像结果与疾病活动度的关联
Sacroiliitis in patients with ankylosing spondylitis: association of MR findings with disease activity.
作者信息
Jee Won-Hee, McCauley Thomas R, Lee Sang-Heon, Kim Sung-Hoon, Im Soo-Ah, Ha Kee-Yong
机构信息
Department of Radiology, Kangnam St. Mary's Hospital, The Catholic University of Korea, Seoul, South Korea.
出版信息
Magn Reson Imaging. 2004 Feb;22(2):245-50. doi: 10.1016/j.mri.2003.09.002.
The purpose of this study was to determine whether MR findings can correlate disease activity as measured by laboratory markers in ankylosing spondylitis. MR images in 19 patients with ankylosing spondylitis were retrospectively analyzed for cartilage abnormality, periarticular erosion, synovial enhancement, and bone marrow edema. Each MR finding was correlated with laboratory inflammatory markers (erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP)) and the sum of ESR + CRP. Synovial enhancement showed a significant correlation with ESR (r=0.58; p<0.01) and increased activity at bone scan (r=0.74; p<0.005), whereas there was no significant correlation with CRP. A significant correlation was found between ESR + CRP and synovial enhancement (r=0.54; p<0.05). Synovial enhancement was more common when ESR + CRP was greater than 30 (p<0.05). In conclusion, synovial enhancement at MR imaging could correlate disease activity as measured by laboratory inflammatory markers in ankylosing spondylitis.
本研究的目的是确定强直性脊柱炎的磁共振成像（MR）表现是否能与通过实验室指标所测量的疾病活动度相关。对19例强直性脊柱炎患者的MR图像进行回顾性分析，观察软骨异常、关节周围侵蚀、滑膜强化和骨髓水肿情况。将每项MR表现与实验室炎症指标（红细胞沉降率（ESR）和C反应蛋白（CRP））以及ESR + CRP之和进行相关性分析。滑膜强化与ESR呈显著相关性（r = 0.58；p < 0.01），且与骨扫描时的活动度增加相关（r = 0.74；p < 0.005），而与CRP无显著相关性。ESR + CRP与滑膜强化之间存在显著相关性（r = 0.54；p < 0.05）。当ESR + CRP大于30时，滑膜强化更为常见（p < 0.05）。总之，强直性脊柱炎患者MR成像中的滑膜强化与通过实验室炎症指标所测量的疾病活动度相关。
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