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通过混浊介质的光学相干断层扫描成像的蒙特卡罗建模。

Monte Carlo modeling of optical coherence tomography imaging through turbid media.

作者信息

Lu Qiang, Gan Xiaosong, Gu Min, Luo Qingming

机构信息

Key Laboratory of Biomedical Photonics, Ministry of Education, Huazhong University of Science and Technology, Wuhan, 430074, China.

出版信息

Appl Opt. 2004 Mar 10;43(8):1628-37. doi: 10.1364/ao.43.001628.

Abstract

We combine a Monte Carlo technique with Mie theory to develop a method for simulating optical coherence tomography (OCT) imaging through homogeneous turbid media. In our model the propagating light is represented by a plane wavelet; its line propagation direction and path length in the turbid medium are determined by the Monte Carlo technique, and the process of scattering by small particles is computed according to Mie theory. Incorporated into the model is the numerical phase function obtained with Mie theory. The effect of phase function on simulation is also illustrated. Based on this improved Monte Carlo technique, OCT imaging is directly simulated and phase information is recorded. Speckles, resolution, and coherence gating are discussed. The simulation results show that axial and transversal resolutions decrease as probing depth increases. Adapting a light source with a low coherence improves the resolution. The selection of an appropriate coherence length involves a trade-off between intensity and resolution.

摘要

我们将蒙特卡罗技术与米氏理论相结合,开发出一种用于模拟光相干断层扫描(OCT)通过均匀浑浊介质成像的方法。在我们的模型中,传播的光由平面小波表示;其在浑浊介质中的线传播方向和路径长度由蒙特卡罗技术确定,小颗粒的散射过程根据米氏理论计算。米氏理论获得的数值相位函数被纳入模型。还阐述了相位函数对模拟的影响。基于这种改进的蒙特卡罗技术,直接模拟了OCT成像并记录了相位信息。讨论了散斑、分辨率和相干选通。模拟结果表明,轴向和横向分辨率随着探测深度的增加而降低。采用低相干光源可提高分辨率。选择合适的相干长度需要在强度和分辨率之间进行权衡。

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