组织淋巴细胞中的γ干扰素/白细胞介素10平衡与黏膜猫免疫缺陷病毒感染的下调相关。
Gamma interferon/interleukin 10 balance in tissue lymphocytes correlates with down modulation of mucosal feline immunodeficiency virus infection.
作者信息
Avery Paul R, Hoover Edward A
机构信息
Department of Microbiology, Immunology and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Colorado 80523, USA.
出版信息
J Virol. 2004 Apr;78(8):4011-9. doi: 10.1128/jvi.78.8.4011-4019.2004.
Abstract
Understanding the early cytokine response to lentiviral infections may be critical to the design of prevention and treatment strategies. By using the feline immunodeficiency virus (FIV) model, we have documented an interleukin 10 (IL10)-dominated response in lymphoid tissue CD4(+) and CD8(+) T lymphocytes within the first 4 weeks after mucosal FIV infection. This profile coincided with the period of high tissue viral replication. By 10 weeks postinfection, tissue viral levels decreased significantly, and gamma interferon (IFN gamma) production in CD8(+) T cells had increased to restore the IL10/IFN gamma ratio to control levels. Concurrently, increased production of IL6 and viral RNA was detected in macrophages. These temporal associations of viral replication with cytokine balance in tissues suggest roles for IL10 in the permissive stage of infection and IFN gamma in the subsequent down modulation of lentiviral infection.
摘要
了解对慢病毒感染的早期细胞因子反应可能对预防和治疗策略的设计至关重要。通过使用猫免疫缺陷病毒（FIV）模型，我们记录了黏膜感染FIV后前4周内淋巴组织CD4(+)和CD8(+) T淋巴细胞中以白细胞介素10（IL10）为主导的反应。这一情况与组织病毒高复制期相吻合。感染后10周，组织病毒水平显著下降，CD8(+) T细胞中γ干扰素（IFNγ）的产生增加，使IL10/IFNγ比值恢复到对照水平。同时，在巨噬细胞中检测到IL6和病毒RNA的产生增加。病毒复制与组织中细胞因子平衡之间的这些时间关联表明，IL10在感染的允许阶段发挥作用，而IFNγ在随后的慢病毒感染下调中发挥作用。
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