一项关于生姜治疗妊娠恶心和呕吐的随机对照试验。
A randomized controlled trial of ginger to treat nausea and vomiting in pregnancy.
作者信息
Smith Caroline, Crowther Caroline, Willson Kristyn, Hotham Neil, McMillian Vicki
机构信息
Department of Obstetrics and Gynaecology, The University of Adelaide, Adelaide, Australia.
出版信息
Obstet Gynecol. 2004 Apr;103(4):639-45. doi: 10.1097/01.AOG.0000118307.19798.ec.
OBJECTIVES
To estimate whether the use of ginger to treat nausea or vomiting in pregnancy is equivalent to pyridoxine hydrochloride (vitamin B6).
METHODS
A randomized, controlled equivalence trial involving 291 women less than 16 weeks pregnant was undertaken at a teaching hospital in Australia. Women took 1.05 g of ginger or 75 mg of vitamin B6 daily for 3 weeks. Differences from baseline in nausea and vomiting scores were estimated for both groups at days 7, 14, and 21.
RESULTS
Ginger was equivalent to vitamin B6 in reducing nausea (mean difference 0.2, 90% confidence interval [CI] -0.3, 0.8), retching (mean difference 0.3; 90% CI -0.0, 0.6) and vomiting (mean difference 0.5; 90% CI 0.0, 0.9), averaged over time, with no evidence of different effects at the 3 time points.
CONCLUSION
For women looking for relief from their nausea, dry retching, and vomiting, the use of ginger in early pregnancy will reduce their symptoms to an equivalent extent as vitamin B6.
LEVEL OF EVIDENCE
I
目的
评估孕期使用生姜治疗恶心或呕吐是否等同于使用盐酸吡哆醇（维生素B6）。
方法
在澳大利亚一家教学医院开展了一项随机对照等效性试验，纳入291名孕周小于16周的女性。女性参与者连续3周每天服用1.05克生姜或75毫克维生素B6。在第7天、第14天和第21天评估两组恶心和呕吐评分与基线的差异。
结果
随着时间推移，生姜在减轻恶心（平均差值0.2，90%置信区间[CI] -0.3，0.8）、干呕（平均差值0.3；90% CI -0.0，0.6）和呕吐（平均差值0.5；90% CI 0.0，0.9）方面与维生素B6等效，在3个时间点均无不同效果的证据。
结论
对于寻求缓解恶心、干呕和呕吐的女性，孕早期使用生姜缓解症状的程度与维生素B6相当。
证据级别
I
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