Gross Harald, Wright Anthony D, Beil Winfried, König Gabriele M
Institute for Pharmaceutical Biology, University of Bonn, Nussallee 6, D-53115 Bonn, Germany.
Org Biomol Chem. 2004 Apr 21;2(8):1133-8. doi: 10.1039/b314332e. Epub 2004 Mar 17.
During the chemical investigation of a new species of soft coral belonging to the genus Sarcophyton, two novel cembranoid compounds with a 12Z double bond (1 and 2) were obtained. Determination of the double bond configurations was done using NMR spectroscopic data and the results of molecular modeling studies. Compound 3, one of several known compounds (3-5), was found to be cytotoxic toward an MCF7 tumor cell line.Additionally, we report the absolute stereochemistry of the cembrane sarcoglaucol-16-one (6), which was determined using the modified Mosher[prime or minute]s method.
在对一种属于肉芝软珊瑚属的新软珊瑚进行化学研究过程中，获得了两种具有12Z双键的新型西松烷类化合物（1和2）。利用核磁共振光谱数据和分子建模研究结果确定了双键构型。化合物3是几种已知化合物（3 - 5）之一，发现其对MCF7肿瘤细胞系具有细胞毒性。此外，我们报道了利用改良的莫舍尔法确定的西松烷类化合物肉芝软珊瑚醇-16-酮（6）的绝对立体化学结构。
