Cossart Pascale, Sansonetti Philippe J
Unité des Interactions Bactéries-Cellules, INSERM Unité 604, Département de Biologie Cellulaire et Infection, Institut Pasteur, 28 Rue du Docteur Roux, Paris 75015, France.
Science. 2004 Apr 9;304(5668):242-8. doi: 10.1126/science.1090124.
Invasive bacteria actively induce their own uptake by phagocytosis in normally nonphagocytic cells and then either establish a protected niche within which they survive and replicate, or disseminate from cell to cell by means of an actin-based motility process. The mechanisms underlying bacterial entry, phagosome maturation, and dissemination reveal common strategies as well as unique tactics evolved by individual species to establish infection.
侵袭性细菌能在通常不具有吞噬作用的细胞中主动诱导自身被吞噬,然后要么在其中建立一个受保护的微环境,使其得以存活和繁殖,要么通过基于肌动蛋白的运动过程在细胞间传播。细菌进入、吞噬体成熟和传播的机制揭示了常见策略以及个别物种为建立感染而演化出的独特策略。