Levine Stephanie M
Department of Medicine, Division of Pulmonary and Critical Care Diseases, University of Texas Health Science Center-San Antonio, 78229, USA.
Chest. 2004 Apr;125(4):1224-38. doi: 10.1378/chest.125.4.1224.
The clinical practice of lung transplantation (LT) varies widely among transplant centers. The objective of this study was to determine the practice patterns of North American lung transplant programs in specific areas that are considered controversial by most lung transplant practitioners.
The Transplant/Immunology Network of the American College of Chest Physicians (ACCP) designed a survey and distributed it through the ACCP using a Web-based survey tool. The survey was divided into the following two sections: (1) patient selection issues; and (2) posttransplant management. Additional questions were asked about graft preservation, retransplantation, and living donor operations. A single 64-question survey was sent to each lung transplant program in the United Sates registered in the United Network of Organ Sharing database as of September 2001 and to each of the five active Canadian programs.
The survey was conducted in September and October 2002. Fifty of 65 active centers completed the survey, for a response rate of 77%. The data are presented in graphic format as a percentage of respondents.
This survey provides a large, time-sensitive database summarizing the clinical practice of LT in North America. In general, the survey responses demonstrated a remarkable degree of consistency around patient selection criteria, but much greater variance in posttransplant management of lung transplant recipients. These findings may reflect the fact that a published selection criteria guideline exists, but no similar documents have been designed for postoperative management. Hopefully, postoperative areas with widely divergent approaches to management will foster future collaborative studies aimed at identifying the most appropriate practices.
肺移植(LT)的临床实践在各移植中心差异很大。本研究的目的是确定北美肺移植项目在大多数肺移植从业者认为存在争议的特定领域的实践模式。
美国胸科医师学会(ACCP)的移植/免疫学网络设计了一项调查,并通过基于网络的调查工具通过ACCP进行分发。该调查分为以下两个部分:(1)患者选择问题;(2)移植后管理。还询问了有关移植物保存、再次移植和活体供体手术的其他问题。向截至2001年9月在美国器官共享联合网络数据库中注册的美国每个肺移植项目以及五个活跃的加拿大项目各发送了一份包含64个问题的单一调查问卷。
该调查于2002年9月和10月进行。65个活跃中心中有50个完成了调查,回复率为77%。数据以图表形式呈现为受访者的百分比。
这项调查提供了一个大型的、对时间敏感的数据库,总结了北美肺移植的临床实践。总体而言,调查回复显示在患者选择标准方面存在显著程度的一致性,但在肺移植受者的移植后管理方面差异更大。这些发现可能反映了这样一个事实,即存在已发表的选择标准指南,但尚未为术后管理设计类似的文件。希望管理方法差异很大的术后领域将促进未来旨在确定最合适实践的合作研究。