McGrath Stephen, Fitzgerald Gerald F, van Sinderen Douwe
National Food Biotechnology Centre, University College, Cork, Ireland.
Curr Opin Biotechnol. 2004 Apr;15(2):94-9. doi: 10.1016/j.copbio.2004.01.007.
The discovery of (bacterio)phages revolutionised microbiology and genetics, while phage research has been integral to answering some of the most fundamental biological questions of the twentieth century. The susceptibility of bacteria to bacteriophage attack can be undesirable in some cases, especially in the dairy industry, but can be desirable in others, for example, the use of bacteriophage therapy to eliminate pathogenic bacteria. The relative ease with which entire bacteriophage genome sequences can now be elucidated has had a profound impact on the study of these bacterial parasites.
(细菌)噬菌体的发现彻底改变了微生物学和遗传学,而噬菌体研究对于解答20世纪一些最基本的生物学问题不可或缺。在某些情况下,细菌对噬菌体攻击的敏感性可能是不利的,尤其是在乳制品行业,但在其他情况下可能是有利的,例如,使用噬菌体疗法来消除病原菌。如今能够相对轻松地阐明完整的噬菌体基因组序列,这对这些细菌寄生物的研究产生了深远影响。