Moore Roger T, Chae K A Mireille, Rhodes Arthur R
Department of Dermatology, Rush Medical College, Rush-Presbyterian-St Luke's Medical Center, 1653 W Congress Parkway, 507 Kidston, Chicago, IL 60612, USA.
J Am Acad Dermatol. 2004 May;50(5 Suppl):S70-4. doi: 10.1016/j.jaad.2003.09.016.
Macular pigmentation of Laugier and Hunziker is an acquired disorder involving lips, oral mucosa, acral surfaces, nail apparatus, or a combination of these in the absence of systemic disease, and is reported to show intraepidermal melanosis without melanocytosis. We present a 69-year-old white man with typical features of this disorder, involving lips and oral mucosa, first appearing 4 years before presentation. A pigmented macule on sun-exposed lip vermilion revealed increased numbers of slightly atypical melanocytes in a lentiginous epidermal pattern. A buccal mucosa pigmented macule and adjacent nonpigmented mucosa were studied using hematoxylin and eosin staining, and S-100 and L-3,4 dihydroxyphenylalanine histochemistry. The buccal mucosa macule revealed markedly increased numbers of dendritic, L-3,4 dihydroxyphenylalanine-reactive intraepithelial melanocytes. Further studies are warranted to determine if this pigmentation disorder represents a spectrum of histopathologic change or, in fact, should be renamed mucocutaneous lentiginosis of Laugier and Hunziker.
劳吉尔和洪齐克尔氏黄斑色素沉着症是一种后天性疾病，累及唇部、口腔黏膜、手足部位、甲器，或这些部位的组合，且无全身性疾病，据报道其表现为表皮内黑素沉着但无黑素细胞增多。我们报告一名69岁白人男性，具有该疾病的典型特征，累及唇部和口腔黏膜，首次出现于就诊前4年。暴露于阳光下的唇红部色素斑显示，在雀斑样表皮模式中有数量增多的轻度非典型黑素细胞。对颊黏膜色素斑及相邻的无色素黏膜进行苏木精-伊红染色、S-100和L-3,4二羟基苯丙氨酸组织化学研究。颊黏膜斑显示树突状、L-3,4二羟基苯丙氨酸反应性上皮内黑素细胞数量明显增多。有必要进一步研究以确定这种色素沉着障碍是否代表一系列组织病理学变化，或者实际上是否应重新命名为劳吉尔和洪齐克尔氏黏膜皮肤雀斑样痣。
