9、12和15月龄时麻疹-腮腺炎-风疹疫苗接种情况比较。

Comparison of vaccination with measles-mumps-rubella vaccine at 9, 12, and 15 months of age.

作者信息

Redd Stephen C, King Gail E, Heath Janet L, Forghani Baghar, Bellini William J, Markowitz Lauri E

机构信息

National Immunization Program, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA.

出版信息

J Infect Dis. 2004 May 1;189 Suppl 1:S116-22. doi: 10.1086/378691.

DOI:10.1086/378691

PMID:15106100

Abstract

To determine seroconversion rates with measles-mumps-rubella vaccine administered to children at 9, 12, or 15 months of age, we undertook a prospective randomized trial. Among children vaccinated at 15 months of age, 98% seroconverted to measles, compared with 95% of those vaccinated at 12 months of age and 87% of those vaccinated at 9 months of age. In each age group, children of mothers born in or before 1963 had lower rates of seroconversion against measles, with the lowest rate in children vaccinated at 9 months. The seroconversion rate of rubella paralleled that of measles, with the lowest seroconversion rates in children vaccinated at 9 months of age whose mothers were born in or before 1963. The response to mumps varied little by age of the child or birth year of the child's mother. These results support the recommended age for first vaccination with measles-mumps-rubella at 12-15 months.

摘要

为确定在9、12或15月龄儿童中接种麻疹-腮腺炎-风疹疫苗后的血清转化率，我们进行了一项前瞻性随机试验。在15月龄接种疫苗的儿童中，98%出现麻疹血清转化，相比之下，12月龄接种疫苗的儿童为95%，9月龄接种疫苗的儿童为87%。在每个年龄组中，母亲出生于1963年或之前的儿童麻疹血清转化率较低，9月龄接种疫苗的儿童中该比率最低。风疹血清转化率与麻疹相似，母亲出生于1963年或之前的9月龄接种疫苗的儿童风疹血清转化率最低。儿童对腮腺炎的反应随儿童年龄或儿童母亲出生年份的变化很小。这些结果支持推荐的12 - 15月龄首次接种麻疹-腮腺炎-风疹疫苗的年龄。