加拿大的麻疹消除工作。

Measles elimination in Canada.

作者信息

King Arlene, Varughese Paul, De Serres Gaston, Tipples Graham A, Waters John

机构信息

Immunization and Respiratory Infections Division, Centre for Infectious Disease Prevention and Control, Population and Public Health Branch, Health Canada, Ottawa, Ontario, Canada.

出版信息

J Infect Dis. 2004 May 1;189 Suppl 1:S236-42. doi: 10.1086/378499.

DOI:10.1086/378499

PMID:15106117

Abstract

To describe the progress and challenges in achieving measles elimination in Canada, we analyzed national data on measles cases for 1998-2001. To assess the status of measles elimination in Canada, we estimated the effective reproductive number, R. Measles elimination was defined as the interruption of endemic transmission and failure to reestablish endemic transmission after importation. Twelve isolated cases, 29 cases (72.4% were linked to 2 outbreaks), 199 cases (96.9% were linked to 4 outbreaks of 2, 6, 30, and 155 cases), and 34 cases (73.5% were linked to 8 outbreaks of 2, 2, 2, 2, 3, 3, 3, and 8 cases) were reported in 1998, 1999, 2000, and 2001, respectively. R ranged from 0.58 to 0.95. Multiple chains of transmission occurred in religious communities that actively oppose or resist immunization efforts. Epidemiological and virological evidence suggests that endemic transmission of measles has been mostly interrupted since 1998.

摘要

为描述加拿大在实现消除麻疹方面的进展和挑战，我们分析了1998 - 2001年全国麻疹病例数据。为评估加拿大消除麻疹的状况，我们估算了有效繁殖数R。消除麻疹的定义为地方性传播中断且输入后未重新建立地方性传播。1998年、1999年、2000年和2001年分别报告了12例散发病例、29例病例（72.4%与2起疫情有关）、199例病例（96.9%与4起疫情有关，分别为2例、6例、30例和155例）以及34例病例（73.5%与8起疫情有关，分别为2例、2例、2例、2例、3例、3例、3例和8例）。R值范围为0.58至0.95。在积极反对或抵制免疫工作的宗教社区出现了多条传播链。流行病学和病毒学证据表明，自1998年以来麻疹的地方性传播大多已被中断。