Bennis S, Chami F, Chami N, Bouchikhi T, Remmal A
Faculté des Sciences, Fès Laboratoire de Biotechnologie, Atlas FES, Morocco.
Lett Appl Microbiol. 2004;38(6):454-8. doi: 10.1111/j.1472-765X.2004.01511.x.
This study aims to bring some information about the mechanism of the fungicidal action of thymol and eugenol; phenolic major components of thyme and clove essential oils respectively. Saccharomyces cerevisiae was used as yeast model.
Treatment of yeast cells with these components led to their lysis as shown by the release of substances absorbing at 260 nm. In addition, scanning electron microscope observations revealed that the surface of the treated cells was significantly damaged.
Antifungal activity of thymol and eugenol involve alteration of both membrane and cell wall of the yeast.
This work is a preliminary contribution aiming to develop a new generation of efficient and natural antifungal agents.
本研究旨在提供一些关于百里香酚和丁香酚杀菌作用机制的信息；百里香酚和丁香酚分别是百里香和丁香精油中的主要酚类成分。以酿酒酵母作为酵母模型。
用这些成分处理酵母细胞导致细胞裂解，表现为在260nm处有吸收的物质释放。此外，扫描电子显微镜观察显示，处理过的细胞表面受到显著损伤。
百里香酚和丁香酚的抗真菌活性涉及酵母细胞膜和细胞壁的改变。
这项工作是一项初步贡献，旨在开发新一代高效天然抗真菌剂。
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