胆汁反流及胃内微生物群变化对胃部手术后残胃黏膜病变的影响。
Effects of bile reflux and intragastric microflora changes on lesions of remnant gastric mucosa after gastric operation.
作者信息
Zhang Chao, Liu Zhan-Kui, Yu Pei-Wu
机构信息
Department of General Surgery, Southwest Hospital, Third Military Medical University, Gaotan Yan, Chongqing 400038, China.
出版信息
World J Gastroenterol. 2004 May 15;10(10):1537-9. doi: 10.3748/wjg.v10.i10.1537.
AIM
To investigate the effects of bile reflux and intragastric microflora changes on lesions of remnant gastric mucosa after gastric operation.
METHODS
Concentration of bile acid and total bacterial counts (TBC) in gastric juice were measured in 49 patients with peptic ulcer before and after gastrectomy. One year after the operation, sample of gastric mucosa taken from all the patients were used for histological examination.
RESULTS
The concentration of gastric bile acid was significantly increased in group B-I, or B-II and SV+A than that in group HSV (P<0.05-0.01). The abnormal histological changes in the remnant gastric mucosa were more common in the first 2 groups than in the last group.
CONCLUSION
The type of gastrectomy can affect bile reflux. The abnormal histological changes in the remnant gastric mucosa are closely related to the elevation of bile acid concentration and increase of TBC in gastric juice. HSV can effectively prevent bile reflux and keep the gastric physiological functions stable.
目的
探讨胆汁反流及胃内微生物群变化对胃手术后残胃黏膜病变的影响。
方法
对49例消化性溃疡患者在胃切除术前及术后测定胃液中胆汁酸浓度和细菌总数（TBC）。术后1年，采集所有患者的胃黏膜样本进行组织学检查。
结果
B-I组、B-II组和SV+A组的胃胆汁酸浓度显著高于HSV组（P<0.05-0.01）。前两组残胃黏膜的异常组织学变化比最后一组更常见。
结论
胃切除类型可影响胆汁反流。残胃黏膜的异常组织学变化与胆汁酸浓度升高及胃液中TBC增加密切相关。HSV能有效预防胆汁反流并保持胃生理功能稳定。
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