三氧化二砷治疗晚期急性早幼粒细胞白血病。
Arsenic trioxide in the treatment of advanced acute promyelocytic leukemia.
作者信息
Carmosino Ida, Latagliata Roberto, Avvisati Giuseppe, Breccia Massimo, Finolezzi Erica, Lo Coco Francesco, Petti Maria Concetta
出版信息
Haematologica. 2004 May;89(5):615-7.
PMID:15136230
Abstract
Eleven patients with advanced APL were treated with ATO (0.15 mg/Kg daily). Eight (73%) achieved molecular CR, but 5 relapsed, 1 died in molecular CR, 1 was lost to follow-up and 1 is still alive in CR after allogeneic transplantation. We suggest that ATO may be effective also in advanced APL, but given the short CR, it seems indicated only in patients eligible for transplant procedures.
摘要
11例晚期急性早幼粒细胞白血病（APL）患者接受了三氧化二砷（ATO，每日0.15mg/Kg）治疗。8例（73%）达到分子学完全缓解（CR），但5例复发，1例在分子学CR时死亡，1例失访，1例在异基因移植后仍处于CR状态存活。我们认为ATO对晚期APL可能也有效，但鉴于缓解期短，似乎仅适用于适合移植手术的患者。
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