Dvorak J, Melichar B, Zizka J, Hadzi-Nikolov D, Petera J
Department of Oncology and Radiotherapy, Charles University Medical School and Teaching Hospital, Hradec Králové, Czech Republic.
Onkologie. 2004 Apr;27(2):171-4. doi: 10.1159/000076908.
Inoperable melanoma brain metastases are usually uniformly fatal, and complete response after cytotoxic therapy is rare.
A patient with multiple inoperable melanoma brain metastases was treated with 6 cycles of oral temozolomide (300 mg once daily over 5 days every 28 days). A complete response was documented by magnetic resonance.
The present observation suggests that temozolomide may be an active and well tolerated treatment for malignant melanoma brain metastases.
无法手术切除的黑色素瘤脑转移瘤通常预后极差，细胞毒性治疗后完全缓解的情况罕见。
一名患有多处无法手术切除的黑色素瘤脑转移瘤的患者接受了6个周期的口服替莫唑胺治疗（每28天中连续5天，每日一次，每次300毫克）。磁共振成像显示完全缓解。
目前的观察结果表明，替莫唑胺可能是治疗恶性黑色素瘤脑转移瘤的一种有效的、耐受性良好的治疗方法。
Zotero 插件