新型4-(3,4-二甲氧基苯基)-2-甲基噻唑-5-羧酸衍生物的设计、合成及生物活性
Design, synthesis, and biological activity of novel 4-(3,4-dimethoxyphenyl)-2-methylthiazole-5-carboxylic acid derivatives.
作者信息
Liu Chang-Ling, Li Lin, Li Zheng-Ming
机构信息
Agrochemical Discovery Department, Shenyang Research Institute of Chemical Industry, Shenyang 110021, China.
出版信息
Bioorg Med Chem. 2004 Jun 1;12(11):2825-30. doi: 10.1016/j.bmc.2004.03.050.
PMID:15142542
Abstract
Novel 4-(3,4-dimethoxyphenyl)-2-methylthiazole-5-carboxylic acid derivatives (11-23) were synthesized from 3,4-dimethoxyacetophenone (5) in six-step procedure. Their biological activities were evaluated in the greenhouse. Some of the compounds had shown fungicidal and insecticidal activities at 375 g ai/ha and 600 g ai/ha, respectively.
摘要
新型4-(3,4-二甲氧基苯基)-2-甲基噻唑-5-羧酸衍生物(11 - 23)由3,4-二甲氧基苯乙酮(5)通过六步反应合成。在温室中评估了它们的生物活性。部分化合物分别在375克有效成分/公顷和600克有效成分/公顷时表现出杀真菌和杀虫活性。
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