原发性开角型青光眼的一氧化氮替代物与眼灌注压
Nitric oxide proxies and ocular perfusion pressure in primary open angle glaucoma.
作者信息
Galassi F, Renieri G, Sodi A, Ucci F, Vannozzi L, Masini E
机构信息
Department of Oto-Neuro-Ophthalmological Sciences, University of Florence, Eye Unit II, Florence, Italy.
出版信息
Br J Ophthalmol. 2004 Jun;88(6):757-60. doi: 10.1136/bjo.2003.028357.
BACKGROUND
To investigate the levels of nitric oxide (NO) markers in plasma and aqueous humour of patients with primary open angle glaucoma (POAG) and their relation to ocular perfusion pressure.
METHODS
Cyclic guanosine monophosphate (cGMP) and nitrite (NO(2)(-)) were determined in plasma and aqueous humour of 38 patients with POAG and 46 controls. Blood pressure and IOP were measured to calculate ocular perfusion pressure (PP).
RESULTS
cGMP and NO(2)(-) plasma levels were significantly decreased in glaucoma patients compared with controls (p = 0.001 v p = 0.004). In the aqueous humour of subjects with POAG, cGMP and NO(2)(-) concentrations were also lower than in normal eyes (p = 0.0001 v p = 0.001). There was a linear association between cGMP in plasma and aqueous humour in glaucomas and controls (r = 0.514, p = 0.029 and r = 0.558, p = 0.004) and this relation differed in the two groups (p = 0.003). Considering glaucoma patients with controls, a positive correlation was found between cGMP and PP (r = 0.379, p = 0.01) and between NO(2)(-) and PP (r = 0.339, p = 0.040). The cGMP/PP correlation was of borderline statistical significance in controls (p = 0.050), whereas it did not attain statistical significance in POAG, as well as the association between NO(2)(-) and PP when glaucomas and controls were considered separately.
CONCLUSIONS
The authors found alterations of NO markers in the plasma and aqueous humour of glaucoma patients. Primary or secondary impaired NO balance could alter ocular perfusion pressure.
背景
研究原发性开角型青光眼（POAG）患者血浆和房水中一氧化氮（NO）标志物水平及其与眼灌注压的关系。
方法
测定38例POAG患者和46例对照者血浆和房水中的环磷酸鸟苷（cGMP）和亚硝酸盐（NO₂⁻）。测量血压和眼压以计算眼灌注压（PP）。
结果
与对照组相比，青光眼患者血浆中cGMP和NO₂⁻水平显著降低（p = 0.001对p = 0.004）。在POAG患者的房水中，cGMP和NO₂⁻浓度也低于正常眼（p = 0.0001对p = 0.001）。青光眼患者和对照组血浆和房水中的cGMP之间存在线性关联（r = 0.514，p = 0.029和r = 0.558，p = 0.004），且两组之间这种关系有所不同（p = 0.003）。将青光眼患者与对照组进行比较，发现cGMP与PP之间存在正相关（r = 0.379，p = 0.01），NO₂⁻与PP之间也存在正相关（r = 0.339，p = 0.040）。cGMP/PP相关性在对照组中具有临界统计学意义（p = 0.050），而在POAG中未达到统计学意义，单独考虑青光眼和对照组时，NO₂⁻与PP之间的关联也未达到统计学意义。
结论
作者发现青光眼患者血浆和房水中NO标志物存在改变。原发性或继发性NO平衡受损可能会改变眼灌注压。
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