浸润白细胞在肿瘤生长和扩散中的作用。
Role of infiltrated leucocytes in tumour growth and spread.
作者信息
Lin E Y, Pollard J W
机构信息
Department of Developmental and Molecular Biology, Center for the Study of Reproductive Biology and Women's Health,Albert Einstein College of Medicine, 1300 Morris Park Ave., Bronx, NY 10461, USA.
出版信息
Br J Cancer. 2004 Jun 1;90(11):2053-8. doi: 10.1038/sj.bjc.6601705.
Leucocytes are a major component of the tumour microenvironment. Recent studies have indicated that the infiltration and activity of these host cells are regulated by the tumour to promote its survival and progression. Through the production of an array of growth factors, proteases and angiogenic mediators, leucocytes in the tumour microenvironment promote tumour growth, angiogenesis and metastasis.
白细胞是肿瘤微环境的主要组成部分。最近的研究表明，这些宿主细胞的浸润和活性受肿瘤调控，以促进其存活和进展。肿瘤微环境中的白细胞通过产生一系列生长因子、蛋白酶和血管生成介质，促进肿瘤生长、血管生成和转移。
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