On the significance of linkage studies of complex traits.
作者信息
Newton-Cheh Christopher, Larson Martin, Kathiresan Sekar, O'Donnell Christopher
出版信息
Am J Hum Genet. 2004 Jul;75(1):151-2; author reply 152-4. doi: 10.1086/422220.
Abstract
摘要
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On the significance of linkage studies of complex traits.
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Meta-analysis of 4 coronary heart disease genome-wide linkage studies confirms a susceptibility locus on chromosome 3q.
Arterioscler Thromb Vasc Biol. 2003 Oct 1;23(10):1863-8. doi: 10.1161/01.ATV.0000093281.10213.DB. Epub 2003 Aug 28.
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Evaluating the results of genomewide linkage scans of complex traits by locus counting.
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Genome-wide linkage analysis of the acute coronary syndrome suggests a locus on chromosome 2.
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A comprehensive linkage analysis for myocardial infarction and its related risk factors.
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A genome-wide scan for coronary heart disease suggests in Indo-Mauritians a susceptibility locus on chromosome 16p13 and replicates linkage with the metabolic syndrome on 3q27.
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