血管间充质细胞的模式形成。
Pattern formation by vascular mesenchymal cells.
作者信息
Garfinkel Alan, Tintut Yin, Petrasek Danny, Boström Kristina, Demer Linda L
机构信息
Department of Medicine, University of California, Los Angeles, 90095, USA.
出版信息
Proc Natl Acad Sci U S A. 2004 Jun 22;101(25):9247-50. doi: 10.1073/pnas.0308436101. Epub 2004 Jun 14.
In embryogenesis, immature mesenchymal cells aggregate and organize into patterned tissues. Later in life, a pathological recapitulation of this process takes place in atherosclerotic lesions, when vascular mesenchymal cells organize into trabecular bone tissue within the artery wall. Here we show that multipotential adult vascular mesenchymal cells self-organize in vitro into patterns that are predicted by a mathematical model based on molecular morphogens interacting in a reaction-diffusion process. We identify activator and inhibitor morphogens for stripe, spot, and labyrinthine patterns and confirm the model predictions in vitro. Thus, reaction-diffusion principles may play a significant role in morphogenetic processes in adult mesenchymal cells.
在胚胎发育过程中，未成熟的间充质细胞聚集并组织形成有特定模式的组织。在生命后期，当血管间充质细胞在动脉壁内组织形成小梁骨组织时，动脉粥样硬化病变中会出现这一过程的病理重演。在此，我们表明，多能成体血管间充质细胞在体外自组织形成的模式可由一个基于分子形态发生素在反应扩散过程中相互作用的数学模型预测。我们确定了条纹、斑点和迷宫状模式的激活剂和抑制剂形态发生素，并在体外证实了该模型的预测。因此，反应扩散原理可能在成人间充质细胞的形态发生过程中发挥重要作用。
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