Ahn Tae-Beom, Kim Jong-Min, Kwon Kyung-Mi, Lee Sang-Hun, Jeon Beom S
Department of Neurology, Seoul National University College of Medicine, and Department of Neurology and Clinical Research Institute, Seoul National University Hospital, Seoul, Korea.
Int J Neurosci. 2004 May;114(5):575-85. doi: 10.1080/00207450490422830.
Dopamine cells derived from neural stem cells were transplanted into the dopamine-denervated striatum in the rat. Survival of the dopamine cells, gliosis, and immunological reaction were examined by immunostaining. Tyrosine hydroxylase immunoreactive (TH+) cells were seen in the needle tract, walls of the lateral ventricle, thalamus, hippocampus, and external and internal capsules for up to 3 weeks examination. Most TH+ cells had mature-looking polygonal shapes with processes. Some cells migrated into the striatum. Behavioral improvement was not seen
将源自神经干细胞的多巴胺能细胞移植到大鼠多巴胺去神经支配的纹状体中。通过免疫染色检查多巴胺能细胞的存活、胶质细胞增生和免疫反应。在长达3周的检查中，在针道、侧脑室壁、丘脑、海马以及外囊和内囊中均可见酪氨酸羟化酶免疫反应性（TH+）细胞。大多数TH+细胞呈具有突起的成熟多边形形状。一些细胞迁移到纹状体中。未观察到行为改善。
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