细胞和小鼠中的血小板衍生生长因子信号传导

PDGF signaling in cells and mice.

作者信息

Tallquist Michelle, Kazlauskas Andrius

机构信息

Deptartment of Molecular Biology, UT Southwestern Medical Center, Dallas, TX 75390-9046, USA.

出版信息

Cytokine Growth Factor Rev. 2004 Aug;15(4):205-13. doi: 10.1016/j.cytogfr.2004.03.003.

DOI:10.1016/j.cytogfr.2004.03.003

PMID:15207812

Abstract

Since its discovery over three decades ago, platelet-derived growth factor (PDGF) has been a model system for learning how growth factors regulate biological processes. For the first several decades investigators used cells grown in tissue culture. More recently, PDGF signaling has also been investigated in mice. This review outlines the advances in these two systems, and highlights some of the directions for future investigation.

摘要

自三十多年前被发现以来，血小板衍生生长因子（PDGF）一直是研究生长因子如何调节生物过程的模型系统。在最初的几十年里，研究人员使用在组织培养中生长的细胞。最近，PDGF信号传导也在小鼠中进行了研究。本综述概述了这两个系统的进展，并强调了一些未来研究的方向。