Nedd8/RUB类泛素蛋白对基于cullin的泛素连接酶的调控。
Regulation of cullin-based ubiquitin ligases by the Nedd8/RUB ubiquitin-like proteins.
作者信息
Parry Geraint, Estelle Mark
机构信息
Department of Biology, Indiana University, Myers Hall 150, 915 East Third Street, Bloomington, IN 47405, USA.
出版信息
Semin Cell Dev Biol. 2004 Apr;15(2):221-9. doi: 10.1016/j.semcdb.2003.12.003.
The expression of the ubiquitin related protein Nedd8/RUB is essential for growth in most organisms. Nedd8/RUB has been shown to modify the cullin subunit of culling-based ubiquitin protein ligases (E3). Neddylation acts to regulate the function of these E3s and organisms with lesions in the neddylation process exhibit severe growth defects. In this review we describe the proteins that participate in neddylation and discuss a model for Nedd8/RUB regulation of ubiquitin ligase function.
泛素相关蛋白Nedd8/RUB的表达对大多数生物体的生长至关重要。Nedd8/RUB已被证明可修饰基于cullin的泛素蛋白连接酶（E3）的cullin亚基。Neddylation作用于调节这些E3的功能，并且在Neddylation过程中存在损伤的生物体表现出严重的生长缺陷。在本综述中，我们描述了参与Neddylation的蛋白质，并讨论了Nedd8/RUB对泛素连接酶功能的调节模型。
Zotero 插件