Dewey Michael E, Chen Chih-Mei
Trent Institute for Health Services Research, Medical School, University Hospital, Nottingham, NG7 2UH, UK.
Int J Geriatr Psychiatry. 2004 Jun;19(6):554-7. doi: 10.1002/gps.1128.
No previous attempt has been made to synthesise information on mortality and neurosis in older people. Our objective was to estimate the influence on mortality of various types of neurosis in the older population.
Data sources were: Medline; Embase; and personal files. Studies were considered if they included a majority of persons aged 65 and over at baseline either drawn from a total community sample or drawn from a random sample from the community. Studies which sampled from a larger age range were also included if it was possible to retrieve results about those aged 65 and over. Samples from health care facilities were excluded. Effect sizes were extracted from the papers and if they were not included in the published papers effect sizes were calculated if possible. No attempt was made to contact authors for missing data.
We found seven reports (six of which used a neurosis diagnosis and one which used a symptom scale). Using Fisher's method we found an increase in mortality which was not significant (p = 0.08).
There have been few studies, and the evidence is weakly in favour of an increased mortality risk.
此前尚未有人尝试综合有关老年人死亡率和神经症的信息。我们的目标是评估老年人中各类神经症对死亡率的影响。
数据来源包括:医学期刊数据库(Medline)、荷兰医学文摘数据库(Embase)以及个人档案。若研究在基线时纳入的多数人员年龄在65岁及以上,且样本来自整个社区样本或社区随机样本,则纳入该研究。若能获取65岁及以上人群的结果,那么从更大年龄范围抽样的研究也予以纳入。排除来自医疗保健机构的样本。从论文中提取效应量,若已发表论文中未包含效应量,则尽可能进行计算。未尝试联系作者获取缺失数据。
我们找到了7篇报告(其中6篇使用神经症诊断,1篇使用症状量表)。采用费舍尔方法,我们发现死亡率有所上升,但不显著(p = 0.08)。
相关研究较少,证据微弱地支持死亡风险增加这一观点。