CART肽增加中脑边缘多巴胺能神经元活性：一项微透析研究。
CART peptide increases the mesolimbic dopaminergic neuronal activity: a microdialysis study.
作者信息
Yang Shu-Chuan, Pan Jenn-Tser, Li Hui-Yun
机构信息
Department of Physiology, School of Medicine, National Yang-Ming University, Taipei 112, Taiwan, ROC.
出版信息
Eur J Pharmacol. 2004 Jun 28;494(2-3):179-82. doi: 10.1016/j.ejphar.2004.05.018.
The effects of cocaine-and amphetamine-regulated transcript (CART) peptide on extracellular concentrations of dopamine metabolites, 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA), in the shell region of the nucleus accumbens (AcbSh) were determined by microdialysis in conscious rats. Intracerebroventricular injections of various doses (0.1-5 microg/5 microl/rat) of CART(55-102) elicited dose-dependent increases of extracellular DOPAC and HVA concentration in the AcbSh, suggesting that CART(55-102) peptide has a psychostimulant-like effect via activation of the mesolimbic dopaminergic system.
通过对清醒大鼠进行微透析，测定了可卡因和苯丙胺调节转录物（CART）肽对伏隔核壳区（AcbSh）细胞外多巴胺代谢产物3,4-二羟基苯乙酸（DOPAC）和高香草酸（HVA）浓度的影响。脑室内注射不同剂量（0.1 - 5微克/5微升/只大鼠）的CART(55 - 102)可引起AcbSh细胞外DOPAC和HVA浓度呈剂量依赖性增加，提示CART(55 - 102)肽通过激活中脑边缘多巴胺能系统具有类似精神兴奋剂的作用。
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