Edgerton V Reggie, Tillakaratne Niranjala J K, Bigbee Allison J, de Leon Ray D, Roy Roland R
Brain Research Institute, University of California, Los Angeles, California 90095, USA.
Annu Rev Neurosci. 2004;27:145-67. doi: 10.1146/annurev.neuro.27.070203.144308.
Motor function is severely disrupted following spinal cord injury (SCI). The spinal circuitry, however, exhibits a great degree of automaticity and plasticity after an injury. Automaticity implies that the spinal circuits have some capacity to perform complex motor tasks following the disruption of supraspinal input, and evidence for plasticity suggests that biochemical changes at the cellular level in the spinal cord can be induced in an activity-dependent manner that correlates with sensorimotor recovery. These characteristics should be strongly considered as advantageous in developing therapeutic strategies to assist in the recovery of locomotor function following SCI. Rehabilitative efforts combining locomotor training pharmacological means and/or spinal cord electrical stimulation paradigms will most likely result in more effective methods of recovery than using only one intervention.
脊髓损伤（SCI）后运动功能会严重受损。然而，脊髓回路在损伤后表现出高度的自主性和可塑性。自主性意味着脊髓回路在脊髓上输入中断后具有执行复杂运动任务的一定能力，而可塑性的证据表明，脊髓中细胞水平的生化变化可以以与感觉运动恢复相关的活动依赖方式被诱导。在制定有助于脊髓损伤后运动功能恢复的治疗策略时，应充分考虑这些特性的优势。与仅使用一种干预措施相比，将运动训练、药理学手段和/或脊髓电刺激模式相结合的康复努力很可能会产生更有效的恢复方法。
