一种具有独特9β-羟基的新型蜕皮甾类化合物以及来自意大利蝇子草亚种山地蝇子草的其他四种蜕皮甾类化合物。

A new ecdysteroid with unique 9beta-OH and four other ecdysteroids from Silene italica ssp. nemoralis.

作者信息

Simon András, Pongrácz Zita, Tóth Gábor, Mák Marianna, Máthé Imre, Báthori Mária

机构信息

Institute for General and Analytical Chemistry, Budapest University of Technology and Economics, Budapest, Szt. Gellért tér 4, H-1111 Hungary.

出版信息

Steroids. 2004 Jun;69(6):389-94. doi: 10.1016/j.steroids.2004.03.009.

DOI:10.1016/j.steroids.2004.03.009

PMID:15219788

Abstract

A new natural ecdysteroid, 9beta,20-dihydroxyecdysone (1) and four related compounds 5alpha-20-hydroxyecdysone (2), 5alpha-2-deoxy-integristerone A (3), integristerone A (4) and 22-deoxy-integristerone A (5) were isolated from the herb of Silene italica ssp. nemoralis. Compound 1 is the C-9 epimer of the known 9alpha,20-dihydroxyecdysone (6) and represents a peculiar steroid skeleton. The structures of the compounds were elucidated by 1D and 2D NMR, IR and MS spectroscopy.

摘要

从意大利蝇子草亚种林地蝇子草的全草中分离得到一种新的天然蜕皮甾体9β,20 - 二羟基蜕皮激素（1）以及四种相关化合物5α - 20 - 羟基蜕皮激素（2）、5α - 2 - 脱氧整合甾酮A（3）、整合甾酮A（4）和22 - 脱氧整合甾酮A（5）。化合物1是已知的9α,20 - 二羟基蜕皮激素（6）的C - 9差向异构体，具有独特的甾体骨架。通过一维和二维核磁共振、红外光谱和质谱对这些化合物的结构进行了鉴定。