弹性组织染色在检测结直肠癌静脉侵犯中的价值。
The value of an elastic tissue stain in detecting venous invasion in colorectal cancer.
作者信息
Vass D G, Ainsworth R, Anderson J H, Murray D, Foulis A K
机构信息
Department of Pathology, Royal Infirmary, Glasgow G4 OSF, UK.
出版信息
J Clin Pathol. 2004 Jul;57(7):769-72. doi: 10.1136/jcp.2003.015826.
BACKGROUND
Venous invasion by tumour is an independent prognostic indicator of both prognosis and risk of development of distant metastases in colorectal carcinoma. The use of special stains to aid its detection in pathology specimens is not currently universally recommended.
AIMS
To determine whether an elastica stain significantly increases the incidence of detection of vascular invasion compared with routinely stained sections.
METHODS
Serial sections from the 75 cases of colorectal carcinoma were stained by haematoxylin and eosin (H&E) only and elastica counterstained with H&E. The incidence of both intramural and extramural venous invasion was recorded and compared with that seen when the tumours were originally reported.
RESULTS
Extramural venous invasion had been noted in 14 of the pathology reports and was seen in 18 cases when only the H&E sections were viewed in the study. It was present in 32 cases when elastica stained sections were analysed. Intramural venous invasion was seen in eight cases on H&E sections and 30 cases on elastica stained sections.
CONCLUSION
The use of elastica stained serial sections to detect venous invasion in tumours should be recommended in guidelines for the reporting of colorectal carcinomas.
背景
肿瘤侵犯静脉是结直肠癌预后及远处转移风险的独立预后指标。目前，病理标本检测中使用特殊染色辅助检测静脉侵犯尚未得到普遍推荐。
目的
确定与常规染色切片相比，弹性组织染色是否能显著提高血管侵犯的检出率。
方法
对75例结直肠癌的连续切片仅进行苏木精和伊红（H&E）染色以及用H&E复染弹性组织。记录壁内和壁外静脉侵犯的发生率，并与肿瘤最初报告时的情况进行比较。
结果
病理报告中有14例发现壁外静脉侵犯，在本研究中仅观察H&E切片时发现18例。分析弹性组织染色切片时，有32例存在壁外静脉侵犯。H&E切片上有8例发现壁内静脉侵犯，弹性组织染色切片上有30例。
结论
在结直肠癌报告指南中，应推荐使用弹性组织染色连续切片来检测肿瘤中的静脉侵犯。
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