The concentration of circulating megakaryocyte progenitors in preterm neonates is a function of post-conceptional age.

作者信息

Saxonhouse Matthew A, Christensen Robert D, Walker Danielle M, Hutson Alan D, Sola Martha C

机构信息

Division of Neonatology, Department of Pediatrics, University of Florida, College of Medicine, P.O. Box 100296, Gainesville, FL 32610-0296, USA.

出版信息

Early Hum Dev. 2004 Jul;78(2):119-24. doi: 10.1016/j.earlhumdev.2004.03.009.

DOI:10.1016/j.earlhumdev.2004.03.009

PMID:15223116

Abstract

Circulating megakaryocyte (Mk) progenitors have been used as a measure of megakaryocytopoiesis in neonates. Prior studies have shown a gestational age-dependent decrease in their concentration, but it is unclear how this process continues after birth in preterm neonates. To answer this question, we quantified the Mk progenitors in the blood of 42 neonates of varying post-conceptional ages (gestational age+days of life). We found an inverse relationship between concentration of circulating Mk progenitors and post-conceptional age (r=-0.54, p=0.0002).

摘要