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当50岁以上患者因急性症状发现糖尿病时,是否应推荐胰腺成像检查?

Should pancreas imaging be recommanded in patients over 50 years when diabetes is discovered because of acute symptoms?

作者信息

Damiano J, Bordier L, Le Berre J P, Margery J, Dupuy O, Mayaudon H, Bauduceau B

机构信息

Service d'Endocrinologie, Hôpital d'Instruction des Armées Bégin, 94160 Saint-Mandé, France.

出版信息

Diabetes Metab. 2004 Apr;30(2):203-7. doi: 10.1016/s1262-3636(07)70111-8.

Abstract

The relationship between diabetes mellitus and cancer of the pancreas is complex and incompletely understood. Nevertheless, it is generally agreed that new-onset diabetes in a patient over 50 Years old is a classical indication of pancreatic cancer. But there is no official directive in France that a scan should routinely be performed in such cases. We have studied 115 patients aged over 50 who were hospitalized for new-onset diabetes (fewer than 30 days) whose instability required insulin treatment. Routine imaging revealed abdominal disorders in 14 patients, 6 (5.2%) of whom were suffering from pancreatic adenocarcinomas. No clinical indication or laboratory test, apart from an unusually severe anorexia, suggested the discovered disorders. We therefore routinely carry out a pancreas scan, preferably by MRI, on all patients over 50 Years old presenting with new-onset diabetes, even if there are not clinical or laboratory indications of cancer. This is the only way in which small pancreatic cancers can be detected, thus providing the best hopes for successful treatment. Unfortunately, too often, this approach also detects only tumors that are already well developed. However, nowadays, it is not conceivable for a clinical team to discharge a patient from hospital with such a serious disease undiagnosed.

摘要

糖尿病与胰腺癌之间的关系复杂且尚未完全明晰。然而,人们普遍认为,50岁以上患者新发糖尿病是胰腺癌的典型指征。但在法国,并无官方指令要求在此类情况下常规进行扫描检查。我们研究了115名50岁以上因新发糖尿病(病程少于30天)住院且病情不稳定需胰岛素治疗的患者。常规影像学检查发现14名患者存在腹部病变,其中6名(5.2%)患有胰腺腺癌。除了异常严重的厌食外,没有任何临床指征或实验室检查提示所发现的病变。因此,对于所有50岁以上新发糖尿病患者,即便没有癌症的临床或实验室指征,我们也常规进行胰腺扫描,最好是通过核磁共振成像(MRI)。这是检测小胰腺癌的唯一方法,从而为成功治疗提供最大希望。不幸的是,这种方法常常也只能检测到已经发展得较大的肿瘤。然而,如今,临床团队不可能让患有如此严重疾病却未被诊断的患者出院。

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