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[法国普通人群中失眠主诉的日间后果]

[Daytime consequences of insomnia complaints in the French general population].

作者信息

Ohayon M M, Lemoine P

机构信息

Stanford Sleep Epidemiology Research Center, School of Medicine, Stanford University, Stanford, California 94303, USA.

出版信息

Encephale. 2004 May-Jun;30(3):222-7. doi: 10.1016/s0013-7006(04)95433-4.

Abstract

Insomnia is a frequent symptom in the general population; numerous studies have proven this. In the past years, classifications have gradually given more emphasis to daytime repercussions of insomnia and to their consequences on social and cognitive functioning. They are now integrated in the definition of insomnia and are used to quantify its severity. If the daytime consequences of insomnia are well known at the clinical level, there are few epidemiological data on this matter. The aim of this study was to assess the daytime repercussions of insomnia complaints in the general population of France. A representative sample (n=5,622) aged 15 or older was surveyed by telephone with the help of the sleep-EVAL expert system, a computer program specially designed to evaluate sleep disorders and to manage epidemiological investigations. Interviews have been completed for 80.8% of the solicited subjects (n=5,622). The variables considered comprised insomnia and its daytime repercussions on cognitive functioning, affective tone, daytime sleepiness and diurnal fatigue. Insomnia was found in 18.6% of the sample. The prevalence was higher in women (22.4%) than in men (14.5%, p<0.001) with a relative risk of 1.7 (95% confidence interval 1.5 to 2) and was twice more frequent for subjects 65 years of age or older compared to subjects younger than 45 years. Approximately 30% of subjects reporting insomnia had difficulties initiating sleep. Nearly 75% of insomnia complainers reported having a disrupted sleep or waking up too early in the morning and about 40% said they had a non-restorative sleep. Repercussions on daytime functioning were reported by most insomnia subjects (67%). Repercussions on cognitive functioning changed according age, number of insomnia symptoms and the use of a psychotropic medication. A decreased efficiency was more likely to be reported by subjects between 15 and 44 years of age (OR: 2.9), those using a psychotropic (OR: 1.5), those reporting at least three insomnia symptoms (OR: 1.4) and women (OR: 1.4). The highest probability of the appearance of concentration difficulties was found in subjects younger than 65 Years, having a depressive disorder and using a psychotropic (15-44 years: OR 19.1; 45-64 years: OR 46.6). Difficulties maintaining attention were 15 times higher in subjects aged between 45 and 64 who were using a psychotropic and had also a depressive disorder. Memory difficulties were three times more likely to be reported by subjects using a psychotropic. At the affective level, irritability was 10 times more likely to be reported by subjects younger than 65 Years who were also using a psychotropic and had a depressive disorder. Independent of the presence of a mental disorder and the use of a psychotropic, subjects between 15 and 44 Years were five times more likely to be irritable following a bad sleep. Feeling depressed after a bad night's sleep was 18 times more likely to occur in subjects aged between 45 and 64 who were using a psychotropic and had a depressive disorder. Feeling anxious after a bad night's sleep was seven times more likely to occur in subjects with a depressive disorder. Daytime sleepiness was reported by approximately 20% of insomnia subjects. This rate was relatively comparable among gender, age groups, presence/absence of a mental disorder and use or not of a psychotropic. However, taking into account the interaction between age, use of a psychotropic and the presence of a mental disorder, subjects younger than 65 years, using a psychotropic and having a depressive disorder were at least 10 times more likely to report daytime sleepiness. Subjects who were suffering the most diurnal symptoms of insomnia were those younger than 65 years. Several factors can be evoked to explain this fact. These subjects were, for the most part, likelier to have a stricter sleep/wake schedule because of constraints imposed by work, studies, child care, etc. Subjects older than 65 Years were generally retired and therefore less prone to sleepiness and to cognitive difficulties. Insomnia consequences were limited due to their inactivity. Complementary studies should be undertaken to describe the daytime repercussions of insomnia for this specific age group of the general population and to measure these repercussions.

摘要

失眠是普通人群中的常见症状;众多研究已证实这一点。在过去几年中,分类逐渐更加强调失眠对日间的影响及其对社会和认知功能的后果。它们现在已被纳入失眠的定义中,并用于量化其严重程度。虽然失眠对日间的影响在临床层面已为人熟知,但关于这方面的流行病学数据却很少。本研究的目的是评估法国普通人群中失眠主诉对日间的影响。借助睡眠-EVAL专家系统(一个专门设计用于评估睡眠障碍和进行流行病学调查的计算机程序),通过电话对一个具有代表性的样本(n = 5622)进行了调查,该样本年龄在15岁及以上。已完成对80.8%(n = 5622)被邀请受试者的访谈。所考虑的变量包括失眠及其对认知功能、情绪状态、日间嗜睡和日间疲劳的日间影响。在样本中发现18.6%的人存在失眠。女性的患病率(22.4%)高于男性(14.5%,p < 0.001),相对风险为1.7(95%置信区间为1.5至2),65岁及以上的受试者与45岁以下的受试者相比,患病率高出两倍。报告失眠的受试者中约30%存在入睡困难。近75%的失眠主诉者报告睡眠中断或清晨过早醒来,约40%的人表示睡眠无恢复感。大多数失眠受试者(67%)报告了对日间功能的影响。对认知功能的影响因年龄、失眠症状数量和使用精神药物而异。15至44岁的受试者(优势比:2.9)、使用精神药物的受试者(优势比:1.5)、报告至少三种失眠症状的受试者(优势比:1.4)以及女性(优势比:1.4)更有可能报告效率降低。在65岁以下、患有抑郁症且使用精神药物的受试者中,出现注意力不集中的可能性最高(15至44岁:优势比19.1;45至64岁:优势比46.6)。在45至64岁、使用精神药物且患有抑郁症的受试者中,维持注意力困难的情况高出15倍。使用精神药物的受试者报告记忆困难的可能性高出三倍。在情绪方面,65岁以下、使用精神药物且患有抑郁症的受试者报告易怒的可能性高出10倍。不考虑精神障碍的存在和精神药物的使用,15至44岁的受试者在睡眠不佳后易怒的可能性高出五倍。在45至64岁、使用精神药物且患有抑郁症的受试者中,睡不好觉后感到抑郁的可能性高出18倍。患有抑郁症的受试者睡不好觉后感到焦虑的可能性高出七倍。约20%的失眠受试者报告有日间嗜睡。这一比例在性别、年龄组、是否存在精神障碍以及是否使用精神药物方面相对相当。然而,考虑到年龄、使用精神药物和精神障碍之间的相互作用,65岁以下、使用精神药物且患有抑郁症的受试者报告日间嗜睡至少高出10倍。受失眠日间症状影响最大的是65岁以下的受试者。可以列举几个因素来解释这一事实。在很大程度上,这些受试者由于工作、学习、照顾孩子等所带来的限制,更有可能有更严格的睡眠/觉醒时间表。65岁以上的受试者通常已退休,因此较少出现嗜睡和认知困难。由于他们活动较少,失眠的后果也较为有限。应开展补充研究,以描述普通人群中这一特定年龄组失眠对日间的影响,并测量这些影响。

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