青霉素过敏的困境与争议

Dilemmas and controversies in penicillin allergy.

作者信息

Thethi Arveen K, Van Dellen R G

机构信息

Division of Allergic Diseases and Internal Medicine, College of Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.

出版信息

Immunol Allergy Clin North Am. 2004 Aug;24(3):445-61, vi. doi: 10.1016/j.iac.2004.03.004.

DOI:10.1016/j.iac.2004.03.004

PMID:15242720

Abstract

Since the initial reports of penicillin and beta-lactam drugs causing allergic reactions, much has been elucidated regarding their pathophysiology and mechanism of action. Despite advances in testing for penicillin allergy, with IgE antibodies and skin tests available for the major and minor determinants of penicillin, these reactions remain a challenge to all physicians. They have characteristically been classified according to mechanism and time. Herein, the authors propose a classification system of penicillin allergy based on immunologic mechanisms.

摘要

自从最初有关于青霉素和β-内酰胺类药物引起过敏反应的报道以来，人们对其病理生理学和作用机制已经有了很多了解。尽管青霉素过敏检测取得了进展，有针对青霉素主要和次要决定簇的IgE抗体检测及皮肤试验，但这些反应对所有医生来说仍然是一个挑战。它们通常根据机制和时间进行分类。在此，作者提出一种基于免疫机制的青霉素过敏分类系统。