Filippova N A, Shetinina L N
Arkh Patol. 1992;54(2):39-45.
23 melanomas having the thickness, according to Breslow, up to 1.5 mm and 12 benign melanocytic tumours are studied. Ultrastructural examination gives additional information for differentiating benign and malignant melanocytic tumours. It is necessary to take into consideration such signs as the number and qualitative properties of melanosomes and premelanosomes, structure of nuclear membrane, that of nucleoli, non-specific microfilaments and mast cell infiltration of the tumour stroma. Some ultrastructural difference between lentigo-melanoma and other histological tumour types are noted.
研究了23例根据布雷斯洛(Breslow)厚度达1.5毫米的黑色素瘤以及12例良性黑素细胞肿瘤。超微结构检查为鉴别良性和恶性黑素细胞肿瘤提供了额外信息。有必要考虑诸如黑素小体和前黑素小体的数量和质量特性、核膜结构、核仁结构、非特异性微丝以及肿瘤基质中的肥大细胞浸润等特征。观察到雀斑样痣型黑色素瘤与其他组织学肿瘤类型之间存在一些超微结构差异。