Therapeutic targeting of the tumor vasculature.

A functional tumor vasculature is essential for tumor growth and metastasis and makes an attractive target for therapy. Both antiangiogenic and antivascular approaches are being developed for this purpose. In this article, the current antiangiogenic and antivascular approaches to cancer therapy, potential for their combination with radiotherapy, methods for identifying new targets on the tumor vasculature, and methods for evaluating new vascular-targeted strategies in in vivo model systems are reviewed.