一种经过修正的统一神经源性假说可以解释慢性恰加斯心脏病的自然病程。

A modified and unifying neurogenic hypothesis can explain the natural history of chronic Chagas heart disease.

作者信息

Dávila Diego F, Donis Jose H, Torres Argenis, Ferrer Jose A

机构信息

Instituto de Investigaciones Cardiovasculares, Departamento de Fisiopatología, Universidad de Los Andes, Apartado Postal 590, 5101 Mérida, Venezuela.

出版信息

Int J Cardiol. 2004 Aug;96(2):191-5. doi: 10.1016/j.ijcard.2003.06.015.

DOI:10.1016/j.ijcard.2003.06.015

PMID:15262032

Abstract

The pathogenesis of chronic Chagas disease still is an unresolved and controversial issue. Parasite persistence and autoimmune responses cannot explain the spectrum of chronic Chagas disease. However, a modified neurogenic hypothesis, concerning the timing and mechanisms responsible for the cardiac parasympathetic damage and for the activation of the sympathetic nervous system and of other neurohormonal systems, unifies cardiac remodelling and neurohormonal activation to explain most of the events of the natural history of Chagas disease.

摘要

慢性恰加斯病的发病机制仍是一个尚未解决且存在争议的问题。寄生虫持续存在和自身免疫反应无法解释慢性恰加斯病的全部症状。然而，一种经过修正的神经源性假说，涉及导致心脏副交感神经损伤以及交感神经系统和其他神经激素系统激活的时间和机制，将心脏重塑和神经激素激活统一起来，用以解释恰加斯病自然病程中的大多数事件。