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主动脉瓣与升主动脉分别置换及联合置换后的临床结果。

Clinical outcomes after separate and composite replacement of the aortic valve and ascending aorta.

作者信息

Sioris Thanos, David Tirone E, Ivanov Joan, Armstrong Susan, Feindel Christopher M

机构信息

Division of Cardiovascular Surgery, Toronto General Hospital and the University of Toronto, 200 Elizabeth Street, Toronto, Ontario, Canada M5G 2C4.

出版信息

J Thorac Cardiovasc Surg. 2004 Aug;128(2):260-5. doi: 10.1016/j.jtcvs.2003.11.011.

Abstract

OBJECTIVES

We sought to compare the clinical profile and outcomes of operations for aortic valve disease and ascending aortic aneurysm in patients treated with aortic valve replacement and supracoronary replacement of the ascending aorta or composite replacement of the aortic valve and ascending aorta (Bentall operation).

METHODS

From 1990 through 2001, 133 patients had aortic valve replacement and supracoronary replacement of the ascending aorta, and 452 patients had Bentall operations. Aortic valve replacement and supracoronary replacement of the ascending aorta was performed in patients who had aortic valve disease and dilation of the ascending aorta, whereas the Bentall operation was performed in patients with aortic root abnormality and ascending aortic aneurysm. Mean follow-up was 4.6 +/- 3.1 years and was 100% complete.

RESULTS

Patients who had aortic valve replacement and supracoronary replacement of the ascending aorta were older (61 +/- 13 vs 52 +/- 16 years, P <.001) and more likely to have aortic stenosis, coronary artery disease, and mitral valve disease than those who had Bentall operations. The use of mechanical valves was equal in both groups (42% for aortic valve replacement and supracoronary replacement of the ascending aorta and 43% for the Bentall operation). Operative mortality was 5% for patients undergoing aortic valve replacement and supracoronary replacement of the ascending aorta and 4% for patients undergoing the Bentall operation (P =.45). Survival at 10 years was 57% +/- 8% for patients undergoing aortic valve replacement and supracoronary replacement of the ascending aorta and 74% +/- 4% for patients undergoing the Bentall operation (P =.04), but the type of operation had no effect on survival. Older age, moderate or severe left ventricular dysfunction, active endocarditis, previous cardiac surgery, and coronary artery disease were independent predictors of death. The freedom from reoperation at 10 years was 95% +/- 5% for patients undergoing aortic valve replacement and supracoronary replacement of the ascending aorta and 94% +/- 3% for patients undergoing the Bentall operation (P =.18). Reoperations were mostly because of tissue valve failure or endocarditis. The risk of valve-related complications was the same in both groups. No patient required reoperation for aortic root aneurysm after having aortic valve replacement and supracoronary replacement of the ascending aorta.

CONCLUSIONS

Aortic valve replacement and supracoronary replacement of the ascending aorta and the Bentall operation provide comparable long-term results. The Bentall operation is more appropriate for patients with aortic root abnormality and a dilated ascending aorta, whereas aortic valve replacement and supracoronary replacement of the ascending aorta is a perfectly acceptable operation for patients with aortic valve disease, normal or mildly dilated aortic sinuses, and a dilated ascending aorta.

摘要

目的

我们试图比较接受主动脉瓣置换术及升主动脉超冠状动脉置换术或主动脉瓣与升主动脉复合置换术(Bentall手术)的主动脉瓣疾病和升主动脉瘤患者的临床特征及手术结果。

方法

1990年至2001年期间,133例患者接受了主动脉瓣置换术及升主动脉超冠状动脉置换术,452例患者接受了Bentall手术。主动脉瓣置换术及升主动脉超冠状动脉置换术用于患有主动脉瓣疾病和升主动脉扩张的患者,而Bentall手术则用于患有主动脉根部异常和升主动脉瘤的患者。平均随访时间为4.6±3.1年,随访完整率为100%。

结果

接受主动脉瓣置换术及升主动脉超冠状动脉置换术的患者年龄较大(61±13岁对52±16岁,P<0.001),与接受Bentall手术的患者相比,更有可能患有主动脉瓣狭窄、冠状动脉疾病和二尖瓣疾病。两组机械瓣膜的使用比例相同(主动脉瓣置换术及升主动脉超冠状动脉置换术组为42%,Bentall手术组为43%)。接受主动脉瓣置换术及升主动脉超冠状动脉置换术患者的手术死亡率为5%,接受Bentall手术患者的手术死亡率为4%(P=0.45)。接受主动脉瓣置换术及升主动脉超冠状动脉置换术患者10年生存率为57%±8%,接受Bentall手术患者为74%±4%(P=0.04),但手术类型对生存率无影响。年龄较大、中度或重度左心室功能障碍、活动性心内膜炎、既往心脏手术史和冠状动脉疾病是死亡的独立预测因素。接受主动脉瓣置换术及升主动脉超冠状动脉置换术患者10年再次手术率为95%±5%,接受Bentall手术患者为94%±3%(P=0.18)。再次手术主要是因为组织瓣膜功能衰竭或心内膜炎。两组瓣膜相关并发症的风险相同。接受主动脉瓣置换术及升主动脉超冠状动脉置换术的患者术后无因主动脉根部瘤需要再次手术的情况。

结论

主动脉瓣置换术及升主动脉超冠状动脉置换术与Bentall手术提供了相似的长期结果。Bentall手术更适合患有主动脉根部异常和升主动脉扩张的患者,而主动脉瓣置换术及升主动脉超冠状动脉置换术对于患有主动脉瓣疾病、主动脉窦正常或轻度扩张以及升主动脉扩张的患者是完全可以接受的手术。

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