在氙气吸入过程中向气体混合物中添加少量二氧化碳的生理影响。

Physiologic implications of adding small amounts of carbon dioxide to the gas mixture during inhalation of xenon.

作者信息

Marks E C, Yonas H, Sanders M H, Love J T, Maxwell C, Schimmerman S

机构信息

Department of Neurosurgery, University of Pittsburgh School of Medicine, Pennsylvania.

出版信息

Neuroradiology. 1992;34(4):297-300. doi: 10.1007/BF00588185.

DOI:10.1007/BF00588185

PMID:1528437

Abstract

In addition to being a physiologically active tracer of CBF, xenon (Xe) in subanesthetic concentrations produces a relatively mild lowering of carbon dioxide (CO2) in the blood and elevation of transcranial Doppler (TCD) velocity. The addition of small concentrations of CO2 (0.4-1.2%) to the inhaled mixture produced no measurable effect on end tidal (P(et)) CO2 or TCD velocity. Cerebral blood flow (CBF) alterations induced by Xe are minimized by allowing P(et)CO2 to fall, permitting quantitative measurement of CBF by the Xe/CT CBF method.

摘要

除了作为脑血流量（CBF）的生理活性示踪剂外，亚麻醉浓度的氙气（Xe）会使血液中的二氧化碳（CO2）相对轻度降低，并使经颅多普勒（TCD）速度升高。在吸入混合物中添加低浓度的CO2（0.4 - 1.2%）对呼气末（P（et））CO2或TCD速度没有可测量的影响。通过允许P（et）CO2下降，可将Xe引起的脑血流量（CBF）变化降至最低，从而允许通过Xe/CT CBF方法对CBF进行定量测量。