具有潜在放射性药物应用的铼的吡啶基硫代卡巴腙配合物。

Pyridylthiocarbazide complexes of rhenium with potential radiopharmaceutical applications.

作者信息

Clarke Carole, Cowley Andrew R, Dilworth Jonathan R, Donnelly Paul S

机构信息

Department of Chemistry, University of Oxford, Chemistry Research Laboratory, 12 Mansfield Road, Oxford OX1 3TA, UK.

出版信息

Dalton Trans. 2004 Aug 21(16):2402-3. doi: 10.1039/B406439A. Epub 2004 Jul 22.

DOI:10.1039/B406439A

PMID:15303150

Abstract

Attachment of a thioamide tethering group provides a modification of the well-known pyridylhydrazine based route to radiolabelling of biomolecules (the HYNIC system) and gives a proligand which gives stable, well-defined chelated derivatives with both Re(v) oxo and Re(III) diazenide cores. Both display previously unknown bonding modes for the pyridylthiocarbazide ligands.

摘要

硫代酰胺连接基团的附着对用于生物分子放射性标记的著名的基于吡啶基肼的路线（HYNIC 体系）进行了改进，并得到一种前体配体，该前体配体与 Re(V) 氧代和 Re(III) 重氮化物核均能形成稳定、明确的螯合衍生物。两者都展示了吡啶基硫代卡巴腙配体以前未知的键合模式。