一种20S蛋白酶体强效且快速可逆抑制剂的鉴定。
Identification of a potent and rapidly reversible inhibitor of the 20S-proteasome.
作者信息
Purandare Ashok V, Wan Honghe, Laing Naomi, Benbatoul Khalid, Vaccaro Wayne, Poss Michael A
机构信息
Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, NJ 08543, USA.
出版信息
Bioorg Med Chem Lett. 2004 Sep 20;14(18):4701-4. doi: 10.1016/j.bmcl.2004.06.084.
PMID:15324891
Abstract
Synthesis and in vitro characterization of novel, lactam boronic acid based, selective, and rapidly reversible inhibitor 14 of the 20S-proteasome is presented.
摘要
本文介绍了新型的基于内酰胺硼酸的20S蛋白酶体选择性快速可逆抑制剂14的合成及体外特性。
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