生长激素及其受体在慢性萎缩性胃炎中的表达及其临床意义。
Expression of growth hormone and its receptor in chronic atrophic gastritis and its clinical significance.
作者信息
Si Jian-Min, Cao Qian, Gao Min
机构信息
Department of Gastroenterology of Sir Run Run Shaw Hospital, Zhejiang University, School of Medicine, Hangzhou 310016, Zhejiang Province, China.
出版信息
World J Gastroenterol. 2004 Oct 1;10(19):2908-10. doi: 10.3748/wjg.v10.i19.2908.
AIM
To investigate the growth hormone (GH) and growth hormone receptor (GHR) expression of and its clinical significance in patients with chronic atrophic gastritis (CAG).
METHODS
A total of 90 cases were enrolled in the study. Thirty were healthy controls, the other 60 patients were divided into two groups according to the endoscopical and histological diagnosis. Blood samples were drawn in the morning (menarche did not occur during the blood extraction in female patients), gastric mucosa was obtained by endoscopy. Serum GH and gastrice mucosal GHR levels were measured using radioimmunoassay (RIA) and En Vinsion technique.
RESULTS
The average GH level was 1.021+/-0.132 microg/L in CAG patients, in controls it was 2.869+/-0.512 microg/L. There was a significant difference between these two groups (P<0.01). The positive rate of GHR in CAG patients was 10%, in controls the rate was 100%. There was a significant difference (P<0.01). There was no significant change of GH level (3.176+/-0.421 microg/L) in patients with gastric carcinoma compared with controls (P>0.05).
CONCLUSION
The study shows that levels of GH and GHR expression are low in CAG patients. CAG pathogenesis has a correlation with mucosal nutrient deficiency, decreased levels of GH and GHR have an adverse effect on the repair and regeneration of CAG. There is no significant change of GH in gastric carcinorma patients, GH dose not play a role in the pathogenesis of gastric cancer.
目的
探讨慢性萎缩性胃炎（CAG）患者生长激素（GH）及生长激素受体（GHR）的表达情况及其临床意义。
方法
本研究共纳入90例患者。其中30例为健康对照，另外60例患者根据内镜及组织学诊断分为两组。于早晨采集血样（女性患者采血时未处于月经期），通过内镜获取胃黏膜。采用放射免疫分析法（RIA）和En Vinsion技术检测血清GH及胃黏膜GHR水平。
结果
CAG患者的平均GH水平为1.021±0.132μg/L，对照组为2.869±0.512μg/L。两组间差异有统计学意义（P<0.01）。CAG患者GHR阳性率为10%，对照组为100%。差异有统计学意义（P<0.01）。胃癌患者的GH水平（3.176±0.421μg/L）与对照组相比无明显变化（P>0.05）。
结论
研究表明，CAG患者的GH及GHR表达水平较低。CAG的发病机制与黏膜营养缺乏有关，GH和GHR水平降低对CAG的修复和再生有不利影响。胃癌患者的GH无明显变化，GH在胃癌发病机制中不起作用。
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