着丝粒黏合剂提供纺锤体信号。

Centromere glue provides spindle cue.

作者信息

Deehan Renée, Heald Rebecca

机构信息

Department of Molecular and Cell Biology, University of California, Berkeley, 311 Life Sciences Addition, Berkeley, CA 94720, USA.

出版信息

Cell. 2004 Sep 3;118(5):529-30. doi: 10.1016/j.cell.2004.08.018.

DOI:10.1016/j.cell.2004.08.018

PMID:15339655

Abstract

During cell division, accurate distribution of the genome by the mitotic spindle requires that sister chromatids remain tethered until the right moment. Studies of an uncharacterized vertebrate protein, Sgo (Salic et al., 2004 [this issue of Cell]), reveal dual roles as a chromosome cohesion factor and a regulator of spindle microtubule dynamics.

摘要

在细胞分裂过程中，有丝分裂纺锤体精确分配基因组需要姐妹染色单体一直保持连接状态直至合适时机。对一种未被鉴定的脊椎动物蛋白Sgo（Salic等人，2004年[本期《细胞》杂志]）的研究揭示了它作为染色体黏连因子和纺锤体微管动力学调节因子的双重作用。