使用新型血小板功能分析仪检测月经过多女性中的血管性血友病。
Use of a new platelet function analyzer to detect von Willebrand disease in women with menorrhagia.
作者信息
James Andra H, Lukes Andrea S, Brancazio Leo R, Thames Elizabeth, Ortel Thomas L
机构信息
Department of Obstetrics and Gynecology, Division of Hematology, Duke University Medical Center, Durham, NC, USA.
出版信息
Am J Obstet Gynecol. 2004 Aug;191(2):449-55. doi: 10.1016/j.ajog.2004.03.009.
OBJECTIVE
The purpose of this study was to assess the usefulness of a new platelet function analyzer in the detection of von Willebrand disease and platelet dysfunction in women with menorrhagia.
STUDY DESIGN
Women with menorrhagia and control subjects were tested with a platelet function analyzer. If the results were abnormal, further testing was performed for possible von Willebrand disease or platelet dysfunction. Results were compared.
RESULTS
Of the 108 women with menorrhagia, 28 had an abnormal platelet function analysis results: 7 results were suggestive of von Willebrand disease; 17 results were suggestive of platelet dysfunction, and 4 results were inconclusive. Of the 100 control subjects, 18 subjects had an abnormal platelet function analysis result: 2 results were suggestive of von Willebrand disease; 12 results were suggestive of platelet dysfunction, and 4 results were inconclusive. The prevalence of suspected von Willebrand disease was 6% among women with menorrhagia and 2% among control subjects. Among white women, the prevalence was 10% compared with 1% among control subjects.
CONCLUSION
We demonstrated that the platelet function analyzer could be used to detect von Willebrand disease in women with menorrhagia.
目的
本研究旨在评估一种新型血小板功能分析仪在检测月经过多女性的血管性血友病和血小板功能障碍方面的实用性。
研究设计
对月经过多的女性和对照受试者使用血小板功能分析仪进行检测。如果结果异常，则针对可能的血管性血友病或血小板功能障碍进行进一步检测。比较结果。
结果
在108例月经过多的女性中，28例血小板功能分析结果异常：7例结果提示血管性血友病；17例结果提示血小板功能障碍，4例结果不确定。在100例对照受试者中，18例受试者血小板功能分析结果异常：2例结果提示血管性血友病；12例结果提示血小板功能障碍，4例结果不确定。月经过多女性中疑似血管性血友病的患病率为6%，对照受试者中为2%。在白人女性中，患病率为10%，而对照受试者中为1%。
结论
我们证明血小板功能分析仪可用于检测月经过多女性的血管性血友病。
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