黑皮质素激动剂二型促黑素增加OLETF大鼠的胰岛素敏感性。
The melanocortin agonist melanotan II increases insulin sensitivity in OLETF rats.
作者信息
Banno Ryouichi, Arima Hiroshi, Sato Ikuko, Hayashi Masayuki, Goto Motomitsu, Sugimura Yoshihisa, Murase Takashi, Oiso Yutaka
机构信息
Department of Metabolic Diseases, Field of Internal Medicine, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan.
出版信息
Peptides. 2004 Aug;25(8):1279-86. doi: 10.1016/j.peptides.2004.05.007.
Effects of peripheral administration of melanotan II (MTII), a melanocortin agonist, on insulin sensitivity and glucose tolerance were examined in Otsuka Long-Evans Tokushima Fatty (OLETF) rats. Subcutaneous administration of MTII with osmotic mini-pumps decreased food intake and body weight in OLETF rats. MTII group showed more sensitivity to insulin compared with that allowed to eat ad libitum or pair-fed group in insulin tolerance tests on day 9. MTII group also showed significantly lower glucose values than ad libitum group in glucose tolerance tests on days 11 and 23. Thus, MTII increased insulin sensitivity and improved glucose tolerance in OLETF rats.
在大冢长-伊万科岛肥胖（OLETF）大鼠中，研究了黑皮质素激动剂黑素皮质素II（MTII）外周给药对胰岛素敏感性和糖耐量的影响。通过渗透微型泵皮下注射MTII可降低OLETF大鼠的食物摄入量和体重。在第9天的胰岛素耐量试验中，与自由进食或配对喂养组相比，MTII组对胰岛素更敏感。在第11天和第23天的糖耐量试验中，MTII组的血糖值也显著低于自由进食组。因此，MTII提高了OLETF大鼠的胰岛素敏感性并改善了糖耐量。
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