Yaqoob M, Bashir A, Zaman S, Ferngren H, Von Dobeln U, Gustavson K-H
Department of Paediatrics, Maternity and Children's Hospital, Al-Qassim, Saudi Arabia.
J Intellect Disabil Res. 2004 Oct;48(Pt 7):663-71. doi: 10.1111/j.1365-2788.2003.00573.x.
One of the main objectives of studying intellectual disability (ID) in children is to explore its causes. A specific aetiological diagnosis is important in determining the prognosis, nature and extent of services needed to support affected children.
Aetiology and risk factors in mild ID were studied in a cohort of longitudinally followed children (6-10 years of age, n = 40) in four population groups in and around Lahore, Pakistan.
The overall prevalence of mild ID was 6.2%. In 22% of the cases the onset of mild ID was prenatal with small for gestational age and multifactorial inheritance as the main underlying factors. During the postnatal period (28% of the cases), social deprivation and malnutrition were the major causes of ID. In a substantial proportion of the cases (50%), the cause of ID could not be traced.
The present study indicates a clear relationship of mild ID with prenatal and postnatal malnutrition and social deprivation. Two independent variables, maternal illiteracy and small head circumference at birth, showed a clear association with the development of mild mental disability among children in the study population.
研究儿童智力残疾(ID)的主要目标之一是探究其病因。明确病因诊断对于确定受影响儿童的预后、所需服务的性质和范围至关重要。
在巴基斯坦拉合尔及其周边四个群体中,对一组纵向随访的儿童(6至10岁,n = 40)进行了轻度ID的病因及风险因素研究。
轻度ID的总体患病率为6.2%。在22%的病例中,轻度ID起病于产前,主要潜在因素为小于胎龄儿和多因素遗传。在出生后阶段(28%的病例),社会剥夺和营养不良是ID的主要原因。在相当一部分病例(50%)中,ID的病因无法查明。
本研究表明轻度ID与产前和产后营养不良及社会剥夺存在明确关联。研究人群中,两个独立变量,即母亲文盲和出生时头围小,与儿童轻度智力残疾的发生存在明显关联。