[自身免疫性疾病的发病机制]
[Pathogenic mechanisms of autoimmune diseases].
作者信息
Bonnotte B
机构信息
Inserm U517, faculté de médecine, service d'immunologie clinique et de médecine interne, centre hospitalo-universitaire du Bocage, Dijon, France.
出版信息
Rev Med Interne. 2004 Sep;25(9):648-58. doi: 10.1016/j.revmed.2004.02.003.
BACKGROUND
Auto-immune diseases are a fascinating but poorly understood group of diseases.
MAJOR POINTS
In this review, we will consider genetic susceptibility to auto-immune diseases, initiation of autoreactivity and changes in pathologic processes. Recent physiopathological hypotheses are detailed with clinical examples.
PERSPECTIVES
A better knowledge of the physiopathological mechanisms would allow the development of more efficacious treatments.
背景
自身免疫性疾病是一类引人入胜但了解甚少的疾病。
要点
在本综述中，我们将探讨自身免疫性疾病的遗传易感性、自身反应性的起始以及病理过程的变化。近期的生理病理假说结合临床实例进行了详细阐述。
展望
更好地了解生理病理机制将有助于开发更有效的治疗方法。
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