黑色素瘤患者前哨淋巴结活检后区域淋巴结转移发生率高。
High incidence of in-transit metastases after sentinel node biopsy in patients with melanoma.
作者信息
Estourgie S H, Nieweg O E, Kroon B B R
机构信息
Department of Surgery, Netherlands Cancer Institute/Antoni van Leeuwenhoek Hospital, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.
出版信息
Br J Surg. 2004 Oct;91(10):1370-1. doi: 10.1002/bjs.4692.
BACKGROUND
The occurrence of in-transit metastases in patients with a tumour-positive sentinel node varies greatly between centres and it has been suggested that the incidence is high in this patient group.
METHODS
The incidence of in-transit metastases in 61 patients who had lymph node dissection because of a tumour-positive sentinel node was compared with that in 60 patients who had palpable nodal metastases dissected.
RESULTS
The incidence of in-transit metastases was 23 per cent in patients with a positive sentinel node and 8 per cent in those with palpable nodes (P = 0.027).
CONCLUSION
Sentinel node biopsy was associated with a higher risk of in-transit metastases. This finding does not support the routine use of sentinel node biopsy in the management of melanoma.
背景
前哨淋巴结肿瘤阳性患者发生途中转移的情况在各中心差异很大，有人认为该患者群体的发生率较高。
方法
将61例因前哨淋巴结肿瘤阳性而行淋巴结清扫术的患者的途中转移发生率与60例因可触及淋巴结转移而行清扫术的患者的发生率进行比较。
结果
前哨淋巴结阳性患者的途中转移发生率为23%，可触及淋巴结转移患者的发生率为8%（P = 0.027）。
结论
前哨淋巴结活检与较高的途中转移风险相关。这一发现不支持在前哨淋巴结活检在黑色素瘤治疗中常规使用。
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