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社区医疗中的抗生素使用:指南一致性与处方必要性

Antibiotic utilisation in community practices: guideline concurrence and prescription necessity.

作者信息

Jelinski Susan, Parfrey Patrick, Hutchinson James

机构信息

Clinical Epidemiology Unit, Faculty of Medicine, Memorial University of Newfoundland, St. John's, Newfoundland, Canada.

出版信息

Pharmacoepidemiol Drug Saf. 2005 May;14(5):319-26. doi: 10.1002/pds.1007.

Abstract

PURPOSE

To evaluate the indications, concurrence with prescribing guidelines and potential necessity for antibiotic (AB) prescriptions written in community practice.

METHODS

We reviewed the charts of all patients with infection-related illnesses seen by family physicians during two random days of regular practice between 1 Oct 1997 and 30 Jan 1998. Guideline concurrence of AB prescribing was assessed using regional AB prescribing guidelines. Likelihood of AB indication for respiratory tract infections was assessed using published clinical practice guidelines for determination of likely viral versus bacterial etiology.

RESULTS

Of 4218 visits captured, 949 (22%) were for newly acquired infections. Sixty four percent (n=604) of consultations for newly acquired infections resulted in an AB prescription. Based on the doctors' diagnoses, 61% of AB prescriptions were concurrent with prescribing guidelines, 10% were for the wrong drug, 20% were not indicated and in 10% of cases a lower line AB was available. For respiratory tract infections, 12% of these infections were likely bacterial, whereas the physicians determined that 56% were bacterial.

CONCLUSIONS

A large proportion of ABs administered in community practices were not in concurrence with community AB prescribing guidelines. Improvements can be made in AB choice and in decisions about likely viral etiology for respiratory tract infections.

摘要

目的

评估社区医疗中开具抗生素(AB)处方的适应症、与处方指南的一致性以及潜在必要性。

方法

我们回顾了1997年10月1日至1998年1月30日期间,家庭医生在两个随机工作日诊治的所有感染相关疾病患者的病历。使用地区性AB处方指南评估AB处方与指南的一致性。使用已发表的临床实践指南评估呼吸道感染中AB适应症的可能性,以确定可能的病毒与细菌病因。

结果

在记录的4218次就诊中,949次(22%)是新发感染。新发感染的会诊中有64%(n = 604)开具了AB处方。根据医生的诊断,61%的AB处方符合处方指南,10%使用了错误的药物,20%无用药指征,10%的病例有更低价的AB可用。对于呼吸道感染,其中12%可能是细菌性的,而医生判定56%是细菌性的。

结论

社区医疗中开具的AB处方很大一部分与社区AB处方指南不一致。在AB的选择以及呼吸道感染可能的病毒病因判断方面可以改进。

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