从倍半硅氧烷高效制备糖簇合物。

Efficient preparation of glycoclusters from silsesquioxanes.

作者信息

Gao Yongjun, Eguchi Atsuko, Kakehi Kazuaki, Lee Yuan C

机构信息

Department of Biology, Johns Hopkins University, 3400 North Charles Street, Baltimore, Maryland 21218, USA.

出版信息

Org Lett. 2004 Sep 30;6(20):3457-60. doi: 10.1021/ol040043a.

DOI:10.1021/ol040043a

PMID:15387522

Abstract

[structure: see text] A new type of glycocluster based on polyhedral oligosilsesquioxanes (POSS) has been efficiently prepared from unprotected mannoside and lactoside employing a convergent approach of thiol-radical addition reaction. The versatility of this approach was demonstrated by functionalization of mannosides and lactosides of different-length spacers.

摘要

[结构：见正文] 基于多面体低聚倍半硅氧烷（POSS）的新型糖簇已通过硫醇-自由基加成反应的收敛方法，由未保护的甘露糖苷和乳糖苷高效制备。不同长度间隔基的甘露糖苷和乳糖苷的功能化证明了该方法的通用性。