组织细胞中抗原的定位；立克次氏体和腮腺炎病毒的抗原
Localization of antigen in tissue cells; antigens of rickettsiae and mumps virus.
作者信息
COONS A H, SNYDER J C
出版信息
J Exp Med. 1950 Jan 1;91(1):31-8, pl. doi: 10.1084/jem.91.1.31.
Abstract
Rickettsiae of epidemic typhus fever and Rocky Mountain spotted fever have been microscopically localized and identified in smears of exudates and tissue sections from infected cotton rats by means of homologous antibody labelled with fluorescein. Epidemic typhus has also been identified in smears from single infected human body lice. Mumps virus antigen has been microscopically localized in the parotid of the experimentally infected monkey by the same method. The antigenic material, probably active virus, was found in the cytoplasm of the acinar cells. Such infected acini were scattered irregularly throughout the gland. Some antigen could be seen in the lumens of the parotid ducts and small amounts were present in the cytoplasm of the epithelial cells lining the ducts.
摘要
通过用荧光素标记的同源抗体，在受感染棉鼠的渗出物涂片和组织切片中，已在显微镜下对流行性斑疹伤寒立克次体和落基山斑疹热立克次体进行了定位和鉴定。在单个受感染人体虱子的涂片上也鉴定出了流行性斑疹伤寒。通过同样的方法，在实验感染猴子的腮腺中，已在显微镜下对腮腺炎病毒抗原进行了定位。抗原物质，可能是活性病毒，在腺泡细胞的细胞质中被发现。这种受感染的腺泡不规则地散布于整个腺体。在腮腺导管的管腔中可见一些抗原，并且在导管内衬上皮细胞的细胞质中也有少量存在。
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