内毒素相关肝毒性对增殖肝细胞影响的研究。

A study of endotoxin-associated hepatotoxicity on proliferating hepatocytes.

作者信息

Shibayama Y, Asaka S, Nishijima A, Nakata K

机构信息

Department of Pathology, Osaka Medical College, Japan.

出版信息

Exp Mol Pathol. 1992 Feb;56(1):70-5. doi: 10.1016/0014-4800(92)90024-6.

DOI:10.1016/0014-4800(92)90024-6

PMID:1547870

Abstract

It is thought that regeneration of the liver provides a state of preparedness for the Shwartzman reaction and contributes to the development of endotoxin-associated massive hepatic necrosis following partial hepatectomy. Therefore we examined endotoxin hepatotoxicity in rats with hepatic regeneration after 35% hepatectomy and in rats with liver cell proliferation induced by lead nitrate. Biochemical and histopathological studies showed no enhanced endotoxin hepatotoxicity in either partially hepatectomized rats or in rats with lead nitrate-induced liver cell proliferation. These results indicate that the development of endotoxin-associated hepatic damage after partial hepatectomy may not relate to regeneration and proliferation of the liver.

摘要

人们认为肝脏再生为施瓦茨曼反应提供了一种准备状态，并促使部分肝切除术后内毒素相关的大量肝坏死的发生。因此，我们研究了35%肝切除术后肝再生大鼠以及硝酸铅诱导肝细胞增殖大鼠的内毒素肝毒性。生化和组织病理学研究表明，部分肝切除大鼠或硝酸铅诱导肝细胞增殖的大鼠中，内毒素肝毒性均未增强。这些结果表明，部分肝切除术后内毒素相关肝损伤的发生可能与肝脏的再生和增殖无关。